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报告题目
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报告人职称
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报告人单位
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联系人及电话
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医学院
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2016年12月22日
（周四）14:00-15:00
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黄家湖校区医学院66202
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Title: Is meiosis expressed gene 1 a target for male based contraception?
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张志兵
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Associated professor，武科大特聘教授
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Vriginia Commonwealth University
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付国庆
13297003005
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欢迎广大师生前往！
校科协、医学院
2016年12月12日
报告人简介
l Associate Professor (research) , Department of Obstetrics/Gynecology and Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, Richmond, VA, USA
l 2010-2015 Chutian Scholar of Hubei Province, Specially-Appointed Professor of WUST
l 2012-2018 Specially-Appointed Professor of WUST
Summary of Dr. Zhang:
l I have been working on the molecular basis of mammalian sperm motility and spermatogenesis. Central pair apparatus is a unique structure present in the motile cilia. In Chlamydomonas, proteins localized in this structure play a single role: regulating/modulating cilia motility. However, I discovered that functions of their mammalian orthologues are significantly different.
Some genes not only translate the proteins that regulate cilia motility, they also translate proteins that regulate ciliogenesis/spermatogenesis. I discovered that these proteins form a complex with molecular motors to transport cargos to build cilia. Disruption of any component in the complex results in failure of transporting cargos and spermatogenesis arrest. This complex
also cross-talks with intraflagellar transport components, that are essential for ciliogenesis. More interesting, I recently discovered that sperm associated antigen 6 (SPAG6), a protein considered to be a component of central apparatus, also regulates cytoskeleton/ microtubule function. The Spag6-deficient mice not only develop sperm motility defect, they also show
spermatogenesis defect, hearing loss, defect in immune synapse, neurotransmitter release and bone development, et al. Expression of SPAG6 is dramatically increased in human cancers; thus, this gene may be a marker for cancer diagnosis and target for treatment. I am investigating the molecular mechanisms of this protein and the potential for cancer diagnosis/treatment.
In addition, I am investigating the roles of SOX transcriptional factors on germ cell maturation. I am currently supported by a NIH award (RO1), and received 4% for a RO3 application in June, 2016, a National Natural Science Foundation of China, and a Natural Science Funds of Hubei Province of China.
